Some of the world known research and publications

This is all the data we have been able to find related to the connection between histamines and SARS-Cov-2 virus that causes Covid-19 as well as the possible beneficial

effects of antihistamines within an early treatment protocol. 

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Azelastine - update 2021

01

CEBINA reports positive findings on the potency of azelastine, a widely used anti-histamine, as anti-COVID-19 approach.

CEBINA identifie un vaporisateur nasal antihistaminique courant comme potentielle approche anti-COVID-19.

02

COVID-19 Treatments: Study Shows Using Dual Antihistamines Such As Cetirizine And Famotidine Helps Pulmonary Symptoms In COVID-19 Patients.

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03

Famotidine, Histamine, Mast Cells and Mechanisms

04

Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study.

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05

Dual-histamine receptor blockade with cetirizine - famotidine reduces pulmonary symptoms in COVID-19 patients.

06

Histamine release theory and roles of antihistamine in the treatment of cytokines storm of COVID-19 September-October 2020.

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07

Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome September 2020.

08

Existing antihistamine drugs show effectiveness against COVID-19 virus in cell testing December 2020.

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09

Some Novel Insights into Vitamin D with Interrelated Factors Determining the Outcome of Patient affected by COVID-19

Short running title: The Perfect Storm

Dr Annwyne Houldsworth

10

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.

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11

Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease 2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the disproportionate effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular comorbidities, however, remain incompletely understood.

12

Histamine and histamine intolerance.

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13

 A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.

14

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets.

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15

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis.

16

Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity...

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17

Reports that the over-the-counter histamine H2 receptor antagonist famotidine could help treat the novel coronavirus disease (COVID-19) appeared from April 2020. We, therefore, examined reports on interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and histamine receptor antagonists...

18

Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19?

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19

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients.

20

Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis.

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21

A team of scientists from the United Kingdom has recently revealed the therapeutic benefits of histamine receptor antagonists in reducing long-term symptoms of coronavirus disease 2019 (COVID-19). 

22

Long-COVID following mild SARS CoV-2 infection: characteristic T cell alterations and response to antihistamines.

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23

Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients.

24

A KZN doctor’s observations and treatment of COVID-19 may reveal a missing element.

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25

A potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19.

26

Histamine utilizes JAK–STAT pathway in regulating cytokine production.

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27

Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2.

28

Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic Review.

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29

Famotidine Against SARS-CoV2: A Hope or Hype?

30

COVID-19 and Multisystem Inflammatory Syndrome, or is it Mast Cell Activation Syndrome?

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31

COVID-19, microthromboses, inflammation, and platelet

activating factor.

32

Identification of SARS-CoV-2 entry inhibitors among already approved drugs.

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33

Mast cells activated by SARS-CoV-2 release histamine which increases IL-1 levels causing cytokine storm and inflammatory reaction in COVID-19.

34

Class A G Protein-Coupled Receptor Antagonist Famotidine as a Therapeutic Alternative Against SARS-CoV2: An In Silico Analysis.

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35

Potential association of mast cells with coronavirus disease 2019.

36

Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2.

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37

No Time to Waste: Real-World Repurposing of Generic Drugs as a Multifaceted Strategy Against COVID-19.

38

Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2.

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39

Antihistamine and cationic amphiphilic drugs, old molecules as new tools against the COVID-19?

40

Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19.

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41

Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis.

42

Brief Summary:

This study is a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of cetirizine and famotidine in reducing the duration of symptoms in patients with COVID-19. Secondary aims are to determine if cetirizine and famotidine decrease severity and duration of symptoms, incidence of hospitalizations, ICU admissions, and death.

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43

Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells.

44

A Review of Its Mechanism of Action and Its Role in COVID-19.

Antidepressants also decrease histamine release from MCs (Ferjan and Erjavec, 1996).

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45

Long-Covid following mild SARS Cov-2 infection: characteristic T cell alterations and response to antihistamines.

46

Highlights

 

•Early cardiac pathology likely caused by vasoconstriction ischemia then anoxia

•Ischemia and anoxia possibly caused by vasoconstriction of cardiac pericyte cells

•Vasoconstrictions likely caused by histamine or SARS-CoV-2 pericyte infection

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47

summary of therapeutic evidence for Covid-19 around the world.

48

The beneficial use of two types of antihistamine drug – known as H1 and H2 histamine antagonists

 

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49

Strategy for managing COVID-19 Dr Chris Newton

50

Refer to proposed evaluation and treatment options for this hypothesis

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51

COVID-19 HISTAMINE THEORY. WHY SHOULD WE APPROVE ANTI-HISTAMINES FOR COVID-19 AS A PROPHYLAXIS AND A TREATMENT?

52

Update on functional inhibitors of acid sphingomyelinase in SARS-CoV-2 infection

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53

Mast cells and Histamine storm an overlooked aspect in Covid-19 and in ventilated patients - potential role of antihistamine.

54

Loratadine is successfully used to fix COVID-19 induced respiratory distress and chest pain.

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55

terrible dizzy spells, crippling fatigue, and heart problems and antihistamines

56

Resolution of symptoms after administration of over-the-counter histamine antagonists.

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57

Covid long : antihistaminiques pour les patients souffrant de séquelles du Covid.

58

Phase 2 Clinical Trial patients with Covid-19

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59

Exploring the association of previous hospitalisation use of medication on the mortality of Covid-19 disease January 2022.